Restorative and Regenerative Neuromodulation
Work from the past 40 years has unraveled a wealth of information on the cellular and molecular mechanisms underlying neural plasticity and its relevance in physiological brain function. Yet, our current knowledge on the specific contribution and interactions of distinct forms of plasticity (including metaplasticity and homeostatic plasticity) in the context of pathological brain states remains limited. Given that a broad range of neurological and psychiatric diseases may be accompanied by severe alterations in neural plasticity, i.e., maladaptive plasticity, which could initiate and sustain the remodeling of neuronal networks under pathological conditions, my presentation aims at emphasizing the relevance and need for restorative and regenerative neuromodulation, which aims at detecting and modulating neural function/plasticity, in specific brain regions, at appropriate points in time during the course of a disease. Along this line, I will present our recent work on cellular and molecular mechanisms of non-invasive magnetic stimulation, which is a promising neuromodulation tool that is already employed in clinics for diagnosis and therapy (=reverse translation).