BrainLinks-BrainTools and the Bernstein Center Freiburg are inviting all members, colleagues and friends to a Bernstein Seminar given by Dr. José (Pepe) Alcami Ayerbe, researcher at the Systemic and Cellular Neurophysiology Group at the Institute of Physiology I:
Beyond heterogeneity: Spatial structure in granule cell networks in the dentate gyrus
Abstract: The dentate gyrus is an input region of the hippocampus, a brain region involved in learning and memory. Only a small fraction of its principal cells, granule cells, is activated at a given time, a phenomenon known as sparse coding. The recruitment of granule cells remains mysterious: we still do not understand what makes specific granule cells fire action potentials. I will present data showing that granule cell activation follows a spatial structure along the radial axis, that is, from more superficial cells to deeper cells. I have explored the morphological and synaptic properties of granule cells along this axis which may underly their recruitment and which altogether suggest different coding strategies of granule cells along the radial axis.