Global views of development
The development of systems ranging from brains to metastases is governed by regulatory factors that control specification trajectories and by cell division patterns that determine lineage relationships. I will illustrate how single-cell RNA sequencing and CRISPR-Cas9 genome editing provide new tools to reconstruct developmental trajectories and lineage trees at very large scales. I will discuss the opportunities and challenges for these technologies to provide new views of brain development (also see McKenna et al. Science 2016; Farrell et al. Science 2018; Pandey et al. Current Biology 2018; Raj et al. Nature Biotechnology 2018).
More about Alex Schier: