CAPRI

CHARACTERIZATION OF PROBE INTERACTIONS WITH BRAIN TISSUE


Relevant for Research Area

A - Foundations

B - Core Technologies


Summary

Rehabilitation of sensory and/or motor functions in patients with neurological diseases is using artificial electrical stimulation and recording from neurons using different types of implants. So far, all available microelectrodes suffer from the same problem, that is long-term viability and biocompatibility. Therefore, it is important to understand the signals that lead to neuroglial activation and find possibilities of targeted intervention to control the glial response, reduce the adverse nature of the reactions and maintain an ideal environment for the brain-electrode interface. In this context, CAPRI aims at a systematic and long-term investigation of probe-tissue interactions. Our interdisciplinary team will concentrate on the mechanical, electrochemical, cellular and molecular changes at the interface between implanted probes and brain tissue by a multi-scale approach. We will apply multi-modal tomographic imaging, implant manufacturing and degradation testing, pre-clinical in vivo probe implantation combined with histological and cellular analysis of the tissue reactions. In addition, we will use subcellular and molecular approaches to identify key molecules responsive for the tissue response. Thus, CAPRI is fully dedicated to the probe / tissue interaction challenge and is designed to make a significant progress in this particular field.


Project Publications

Böhm T, Joseph K, Kirsch M, Moroni R, Hilger A, Osenberg M, Manke I, Johnston Midori, Stieglitz T, Hofmann UG, Haas CA, Thiele S. Quantitative synchrotron X-ray tomography of the material-tissue interface in rat brain cortex implanted with flexible neural probes (submitted).

Böhm T, Johnston M, Kilias A, Joseph K, Asplund M, Hofmann UG, Thiele S, Stieglitz T, Haas CA. Semi-automated quantification of the CNS immune response at the probe-tissue-interface (in preparation).

Other publications
Böhm T, Joseph K, Kirsch M, Moroni R, Hilger A, Manke I, Johnston M, Asplund M, Vomero M, Hofmann UG, Stieglitz T, Haas CA, Thiele S. X-ray tomographic 3D reconstruction of the brain-probe-interface in rat cortex. GRC Neuroelectronic Interfaces, Galveston, USA, 2018.

Kirsch M, Böhm T, Joseph K,  Asplund A, Hofmann UG, Thiele S, Stieglitz T, Haas CA. Molecular and structural characterization of probe-tissue interactions in the rat brain. GRC Neuroelectronic Interfaces, Galveston, USA, 2018.

Johnston M, Böhm T, Joseph K, Asplund M, Hofmann UG, Thiele S, Haas CA. Semi-automated quantification of the CNS immune response at the probe-tissue-interface. Annual Meeting of the Neuroscience Society, San Diego, USA, 2018.

Stieglitz T, Vomero M, Joseph K, Johnston M, Ciarpella F, Kirsch M, Böhm T, Fadiga L, Thiele S, Haas CA, Hofmann UG, Asplund M. How flexibility and probe size influence chronic reliability: A study on batch processed polyimide-based intracortical neural arrays. Annual Meeting of the Neuroscience Society, San Diego, USA, 2018. 

Johnston M, Böhm T, Joseph K, Asplund M, Follo M, Hofmann UG, Thiele S, Kirsch M, Haas CA. Molecular and structural characterization of probe-tissue interactions in the rat brain. 11th FENS Forum, Berlin, Germany, 2018