CLINICAL EVALUATION OF MICRO ELECTRODE RECORDINGS IN HUMAN PATIENTS
Relevant for Research Area
PD Dr. Tonio Ball (Contact PI)
Micro-electrode recordings play a prominent role in neurotechnological research. They are an excellent tool for basic neuroscience, as they enable access to the activity of single neurons (single-unit activity, SUA), or to multiple cells together (multi- unit activity, MUA). To exploit micro-recordings, we assess their usefulness in the field of epilepsy. In the future, we plan to study the effects of electrical stimuli on SUA, combine SUA with signals recorded simultaneously at different spatial scales (e.g. macro-contacts of depth electrodes) and strengthen the cooperation with computer science. We will focus on adapting novel methods for information extraction from SUA and study solutions for data compression that are needed for wireless systems. In summary, the present project adds the unique opportunity of micro-recordings of human brain activity as an important component to the toolbox of BrainLinks-BrainTools.
We were able to demonstrate several highly promising applications, for instance a novel potential signature of interictal activity inside and outside the seizure onset zone. Furthermore, we showed that signal relations (strong correlation of high-gamma power in LFP with SUA) previously described solely in animal studies could also be revealed by means of our human micro-recordings.
Heers M, Helias M, Hedrich T, Dümpelmann M, Schulze-Bonhage A, Ball T Spectral bandwidth of interictal fast epileptic activity characterizes the seizure onset zone. 2018 Neuroimage-clin, volume: 17, page(s): 865 - 872
Zijlmans M, Worrell GA, Dümpelmann M, Stieglitz T, Barborica A, Heers M, Ikeda A, Usui N, Le Van Quyen M How to record high-frequency oscillations in epilepsy: A practical guideline. 2017 Epilepsia, volume: 58, issue: 8, page(s): 1305 - 1315