A circuit model for addiction – cellular mechanisms & therapeutic implication.
Drug addiction is a behavioral disease defined by the compulsive seeking and taking of a substance despite major negative consequences. Here I will argue that pathological behaviour is the consequence of excessive dopamine release causing specific forms of synaptic plasticity. I will discuss experiments where plasticity mechanisms are used to reverse drug-adaptive behaviour, establishing links of causality and a roadmap for rational therapies.
Learn more about our guest Christia Lüscher http://www.addictionscience.unige.ch/lab
The talk is part of our Freiburg Neuroscience & Neurotechnology Lectures Series.