In a recently published research article, the groups led by Prof. Dr. MD. Volker Coenen and Prof. Dr. Thomas Stieglitz collaborated on establishing a sensing methodology that enables long-term monitoring of stimulation-induced dopaminergic projections in a rat model. This work, for the first time, presents a roadmap for utilizing the fiber photometry technique in combination with the dopamine indicator (GRABDA2m), offering stable in vivo readouts over at least 14 days. The publication has been awarded as the top second in the released editor’s choice by the journal of brain-sciences. This collaborative research has been shaped under the cluster effort of BrainLinks-BrainTools and has focused on interfacing medical/biological demands with advanced engineering solutions.
Original publication: Miguel Telega, L.; Ashouri Vajari, D.; Stieglitz, T.; Coenen, V.A.; Döbrössy, M.D. New Insights into In Vivo Dopamine Physiology and Neurostimulation: A Fiber Photometry Study Highlighting the Impact of Medial Forebrain Bundle Deep Brain Stimulation on the Nucleus Accumbens. Brain Sci. 2022, 12, 1105. https://doi.org/10.3390/brainsci12081105
Miguel Telega, L., M.Sc., conducts her PhD research at the Lab of Stereotaxy and Interventional Neurosciences (SIN), the research facility of Dept. of Stereotactic and Functional Neurosurgery led by Prof. DR. MD. Volker A. Coenen.
Danesh Ashouri Vajari, Dr.-Ing, is a PostDoc researcher at the chair for Biomedical Microtechnology (BMT- IMTEK) led by Prof. Dr.-Ing. Thomas Stieglitz based at IMBIT campus.
PD Dr Máté D Döbrössy, PhD
Group Leader, Lab of Stereotaxy and Interventional Neurosciences (SIN)
Dept. of Stereotactic and Functional Neurosurgery and BrainLinks-BrainTools
University Freiburg - Medical Centre