New member in BrainLinks-BrainTools

PD Dr. Ute Häussler, head of the Translational Epilepsy Research Lab, was accepted as full member.

Our research focuses on the structural and functional alterations that underlie two frequent forms of pharmacologically intractable epilepsies (mesial temporal lobe epilepsy (MTLE) and focal cortical dysplasia (FCD)) and the development of better strategies for diagnosis and therapy. We use animal models for epilepsy to understand the processes that lead to epilepsy and how to interfere with these on the molecular level, e.g. by interfering with inflammatory or plasticity processes. In addition, we want to understand where and why the brain generates epileptic seizures and how we have to select targets, frequencies and methodology to perform deep brain stimulation for successful seizure suppression. Our results in animal models are compared with analyses of human brain tissue from curative epilepsy surgery to strengthen the translational aspect of our ideas and concepts. Finally, we contribute to the development of new intraoperative diagnosis methods, which aim to improve operative outcome (seizure-freedom) with minimal side effects.

Being part of BrainLinks-BrainTools as an associated member we already profited a lot from the structures of the research center and, most importantly from fruitful collaborations. Discussions with people from different backgrounds about a topic often led to inspiring new ideas on the one hand and to need-based development of equipment like multi-channel electrodes on the other hand. I am sure that the integration into the center BrainLinks-BrainTools as a full member will be a basis for more such collaborations in the future. Based on our expertise, we provide a platform for testing new devices in vivo and in vitro under disease conditions in animals as well as in human tissue.

More about the research group is available at www.uniklinik-freiburg.de/neurochirurgie/forschung/epilepsie.html