Gastvortrag von Katarzyna Krukiewicz (Schlesische Technische Universität, Polen)BrainLinks-BrainTools lädt alle Mitglieder, Kollegen und Freunde zu einem Gastvortrag (in engl. Sprache) von Katarzyna Krukiewicz von der Schlesischen Technischen Universität in Gleiwitz (Polen) ein:
Poly(3,4-ethylenedioxypyrrole) – novel conjugated polymer with biomedical applications
Abstract: Biomedical engineering requires constant development of new types of biomaterials with specific properties. Conjugated polymers have found to be promising materials applicable in the field of biosensors, artificial scaffolds and neural probes. Nevertheless, only several conjugated polymers exhibit biocompatibility and stability which are properties necessary for such type of applications. Poly(3,4-ethylenedioxypyrrole), PEDOP, is a novel conjugated polymer which is the most promising candidate to become an alternative for polypyrrole and poly(3,4-ethylnedioxythiophene) in a field of electroactive biomaterials. PEDOP combines the most desirable properties of PPy and PEDOT: it has lower polymerization potential than PEDOT and, simultaneously, is more stable than PPy. In this study, the description of physicochemical properties of PEDOP matrix is presented, involving electrochemical (cyclic voltammetry), spectroscopic (UV-Vis, Raman, EPR) and microscopic (SEM) analysis. PEDOP is used for the first time as a drug carrier for three model drugs – ibuprofen, quercetin and ciprofloxacin. Ibuprofen is a popular non-steroidal anti-inflammatory and analgesic drug showing the ability to enhance wound healing. Quercetin is one of flavonoid drug with wide spectrum of activities, while Ciprofloxacin mainly treats bacterial infections caused by Gram-positive and Gram-negative bacteria. The process of drug immobilization is realized with the use of electrochemical techniques, i.e. cyclic voltammetry and chronoamperometry. The efficiency of drug immobilization is studied by means of UV/Vis spectrophotometry. Raman spectroscopy and scanning electron microscopy are used to analyze structural and surface properties of polymer matrices.
C.V.: Katarzyna Krukiewicz did her PhD in electrochemistry with Prof. Jerzy K. Zak and Prof. Mieczyslaw Lapkowski at the Silesian University of Technology, Gliwice, Poland. She has been a Marie Curie Fellow in the Institute of Problems of Chemical Physics Russian Academy of Science, a secondee to the Electron Carbon Nanomaterials Group in the Department of Materials Science and Metallurgy at the University of Cambridge, and Helmholtz-Zentrum für Materialien und Energie in Berlin. Her research interests include electrosynthesis, biomedical applications of conducting polymers and surface functionalization.
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