OPTIMIZING STN-DBS TOWARDS THE ALLEVIATION OF STIMULATION-INDUCED COGNITIVE SIDE EFFECTS
Relevant for Research Area
Dr. Christoph Kaller (Contact PI)
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment of Parkinson’s disease (PD) to alleviate cardinal motor symptoms. Side effects on cognitive functions however suggests that STN-DBS affects regions beyond the targeted basal ganglia, particularly the prefrontal cortex (PFC). We established multi-channel near-infrared spectroscopy (NIRS) for the detection of dysfunctional patterns in the hierarchical processing in the PFC following STN-DBS. Clinical determinants that moderate the extent of STN-DBS side-effects on PFC functioning were identified, such as the volume of activated tissue, the levodopa equivalent dose, and the disease duration before DBS surgery. We further developed a high-performance NIRS device providing a substantially enhanced spatial and temporal sampling, full coverage of the PFC, and multi-distance tomographical measurements, thereby allowing for in-depth resolution and to correct for extra-cerebral signal contributions.
ODASIC has put forward a novel non-invasive optical imaging approach to measure remote network effects of STN-DBS on the PFC that are related to stimulation-induced impairments in cognitive functioning and patients’ quality of life. For future closed-looped applications on individually tailored optimizations of STN-DBS this approach provides a unique basis for defining patient-specific boundaries within which stimulation parameters can be adjusted free of aversive side effects on cognition.